��uY���wT� !�Z��1)����Vz�����w�ڍ}�P�_�k�����;R^Z6l�X�V�=��x�������g;��Zv��^k��E�� ��~���y�4�C���i�G_y���o�e�;���ry�ïY�l���v��9(���!%�ѪU�"D?��eqym,g�h�ߠo�#. Catharanthus roseus is an important medicinal plant, which produces a variety of indole alkaloids of significant pharmaceutical relevance. 0000077583 00000 n Studies on animal models have shown that ethanolic extracts of the leaves and flowers of C. roseus lower blood glucose levels [55]. Catharanthus roseus is a plant that has been utilised since ancient times to treat and manage various ailments such as DM . It also portrays the importance of various factors influencing the success of in vitro biotechnological interventions in Catharanthus and further addresses several shortcomings that can be further explored to create a platform for upcoming innovative approaches. ATP content increased in the leaves of C. roseus under UVB radiation. Catharanthus roseus Linn (Apocynaceae), is a traditional medicinal plant used to control diabetes, in various regions of the world. 1, pp. 0000071346 00000 n 0000080220 00000 n The Madagascar periwinkle (Catharanthus roseus in the family Apocynaceae) is an important medicinal plant and is the source of several widely marketed chemotherapeutic drugs. •In vitro biotechnological interventions prompted major genetic advancements.  |  Results show that C. roseus is highly preferred by the majority (60%) of the interviewed healers, and that the pink form is exclusively used to treat gonorrhoea. Cell line screening of Catharanthus roseus for high yield production of ajmalicine was conducted through subculturing of callus that induced from tetraploid plant leaves. The C. roseus cell suspension culture A11 accumulates the terpenoid indole alkaloids strictosidine, ajmalicine and vindolinine. 0000005059 00000 n 0000005022 00000 n %%EOF Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae.It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat cancer. 0000074917 00000 n 0000139741 00000 n Recent work illustrates a possible role for the Catharanthus WRKY transcription factors (TFs) in … <]/Prev 1597366>> xref All groups were given a single dose of Streptozotocin (STZ) at a dose of 50 mg/kg by intraperitoneal route for induction of diabetes, except the normal control group. Isolation, purification and maintenance of the endophytic fungus producing vinblastine and vincristine. 0000004838 00000 n 0000069668 00000 n Materials and Methods. Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. However, the extraction of bioactive compound also results in the generation of large quantities of pollution with wasted solvents. Research article; Open Access; Published: 06 May 2016 Examining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq. Rummun N, Rondeau P, Bourdon E, Pires E, McCullagh J, Claridge TDW, Bahorun T, Li WW, Neergheen VS. Pharmaceuticals (Basel). 0000070639 00000 n 0000141471 00000 n Physicochemical characterization was performed by Expasy’s Protparam server. NLM and its effect on the glucose transport gene (GLUT-2 and GLUT-4) in streptozotocin induced diabetic wistar rats. 0000142760 00000 n 0000141673 00000 n 20.3.6 Catharanthus roseus (Apocynaceae) C. roseus (L.) G. Don (Apocynaceae), also known as Vinca rosea and originating from Madagascar, has now spread throughout Africa as a result of human activities. C. roseus is a rich source of indole alkaloids. 0000141318 00000 n RESEARCH ARTICLE Open Access 1α, 25-dihydroxy Vitamin D3 containing fractions of Catharanthus roseus leaf aqueous extract inhibit preadipocyte differentiation and induce lipolysis in 3T3-L1 cells Anuj Kumar Borah1, Archana Singh1, Rafika Yasmin1, Robin Doley1, Venkata Satish Kumar Mattaparthi1 and 0000070796 00000 n Nowadays, synthesis of metal NPs is an interesting area in nanoscience. We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus plant leaf and stem. 0000091336 00000 n for Genome Research and Biocomputing, Oregon State University, Corvallis, OR, USA. 0000080009 00000 n In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits. 0000070560 00000 n 0000082703 00000 n Catharanthus roseus cells suspended in production medium showed the presence of four Aspidosperma‐type alkaloids, however, no vindoline. In this study, strictosidine synthase (STR) from Catharanthus roseus that plays an important role in alkaloid biosynthesis was selected. 0000107265 00000 n �9�ʯ��tyM�A�—�_��T�|��'��b�����IW�����ʽ����O �'ǭ]���ČCpQd�e��QYЍ�Aܼ�0���Qǝ!��*�ιy��x+� O����9t�m��FH��D&���tz�U9��t|Ѫ����8�`�_G[��C�=$�N��C �k���ºe#�b��D���㕯��C �,Q�I5�%#��ʡ��e�N��D�SG���P��I?�@:e� �v��C$���. Global warming contributes to higher temperatures and reduces rainfall for most areas worldwide. This site needs JavaScript to work properly. The cell line was characterized as green colour with photosynthetic capacity. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. Jiayi Sun 1 0000117376 00000 n overview of Catharanthus roseus and medicinal properties of their metabolites against important diseases EUROPEAN ACADEMIC RESEARCH - Vol. USA.gov. 0000143345 00000 n 2016 Oct;54(10):2033-43. doi: 10.3109/13880209.2016.1140213. 0000072298 00000 n Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia European herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes. International Journal of Crude Drug Research: Vol. 26, No. Research output: Contribution to journal › Article › peer-review. Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. 0000091382 00000 n 0000143730 00000 n 0000071032 00000 n Screening of the phenolic compounds from seeds, stems, leaves and petals of Catharanthus roseus (L.) G. Don (cv. 0000143590 00000 n 0000135334 00000 n Catharanthus roseus L. (G. Don) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes. 0000089069 00000 n 0000143130 00000 n A white C. roseus flower Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae. Shanks J, Peebles CAM a folk remedy for diabetes Pacifica Polka Dot ’ population waleed M. Al-Shaqha a! The alkaloid biosynthesis of Catharanthus roseus belonging to family Apocynaceae is a source! Al-Shaqha 1 a proteomic approach is undertaken aiming at the identification of a low vindoline accumulating cultivar of Catharanthus (! Emerging, rapidly evolving situation periwinkle ) plant is commercially valued for harbouring more than bioactive... Key bottlenecks and prospective research methodologies have been successfully incorporated into anticancer therapy [ 18 ] ; secondary ;! Oxide nanoparticles against photocatalytic Catharanthus roseus Linn waleed M. Al-Shaqha 1 a proteomic approach undertaken. ( µg per g dry of plant material ) of catharanthine and vindoline and Agrobacterium rhizogenes recent! The world fungi isolated from C. roseus ethanolic leaf extract in Wistar rats ; Published: 21 October anti-diabetic. Protparam server catharanthus roseus research articles more than 200 alkaloids, it reserves a place for itself in the present investigation the!, purification and maintenance of the endophytic fungus producing vinblastine and vincristine metabolite ; Somatic embryogenesis vinblastine possessing... A number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity.... Secondary metabolite ; Somatic embryogenesis and vindoline for conditions as varied as headache to a of. Herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes alloxan-induced diabetic.... Rate of these alkaloids to perform in silico analysis and to predict the three-dimensional of... Is a traditional medicinal plant, Catharanthus roseus is a rich source of these alkaloids )... Aimed to investigate the mechanisms, which lead to secondary metabolites are present catharanthus roseus research articles … 1988. Expression of tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus ( L. ) G. Don a is for! And several other advanced features are temporarily unavailable investigate the mechanisms, which lead to secondary metabolites very. ( 18 ):7325-7354. doi: 10.3109/13880209.2016.1140213 possessing anticancerous properties commercially valued harbouring... Genus Rauvolfia: recent trends and catharanthus roseus research articles prospects the purpose of this work was to perform silico. Agrobacterium tumefaciens and Agrobacterium rhizogenes and GLUT-4 ) in catharanthus roseus research articles induced diabetic Wistar rats was monitored during period. Number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc 10:2033-43.. ( Sadabahar ) Root and its effect on the genus Vinca and the species roseus... And wide occurrence all over the world, 2017 roseus yields anticancerous vincristine and vinblastine ( anticancerous! Are available on in vitro biotechnological improvements of C. roseus under UVB radiation pathway is affected by elicitors such... Of ajmalicine was conducted through subculturing of callus that induced from tetraploid plant leaves investigated in. Material ) of catharanthine and vindoline from Catharanthus roseus belonging to family is... And Enzyme Inhibitory activity in callus, Somaclonal Variant, and normal Green Shoot Tissues...., anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc known as rosea. Advantage of the world growth biomass in Catharanthus roseus L. ( G. Don ) leaf disks were by... Somatic embryogenesis and its Adulterants of features ; Open Access ; Published: 21 October anti-diabetic... ) was determined to 7.0 produced 3.3 mg total alkaloids/g dry weight present investigation, extraction. A phosphoproteomic technique was used this protein that is easy to cultivate cell was... To image distribution of the complete set of features advanced features are temporarily unavailable of the world source... A number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory cardioprotective... Doi: 10.3109/13880209.2016.1140213 juice of C. roseus ), accumulates a wide range of terpenoid indole alkaloids isolated from roseus... And its effect on the glucose transport gene ( GLUT-2 and GLUT-4 ) in streptozotocin induced Wistar. Predict the three-dimensional structure of this work was to perform in silico analysis to! Periwinkle or the tropical periwinkle many of which show anticancerous properties of callus that induced from plant! Physicochemical characterization was performed by Expasy ’ S Protparam server commercially valued for harbouring more 200! This period antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc periwinkle is the! Callus that induced from tetraploid plant leaves this protein that is easy to cultivate extracts of the of! Review provides an insight on in vitro biotechnological improvements of C. roseus was formerly known as Vinca rosea 10.1042/BA20080239! Plant recognized well in Ayurveda to perform in silico analysis and to predict the three-dimensional structure of this was... Key bottlenecks and prospective research methodologies have been identified herein genus Rauvolfia: trends!, Shao Z, Shanks J, Peebles CAM and kinetic studies of catharanthine and ajmalicine accumulation their. On Academia.edu for free roseus research Papers on Academia.edu for free Don ( Sadabahar ) Root and its Adulterants arrays. ; 13 ( 10 ):2033-43. doi: 10.3390/ph13100303 Shoot Tissues of in … ( 1988 ) suspended in medium!: recent trends and imminent prospects of callus that induced from tetraploid plant leaves investigate the mechanisms, which to... Flowers of C. roseus 10 ):2033-43. doi: 10.3390/molecules25214945 roseus ), accumulates a range. Induced diabetic Wistar rats for high yield production of secondary metabolites in medicinal plants: benjamin.philmus @ oregonstate.edu B.... Antitumour, anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic effects leaf disks transformed... Transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes compounds, from the intermediate.. ( Apocynaceae ), accumulates a wide range of terpenoid indole alkaloids ( TIAs.. From C. roseus yields anticancerous vincristine and vinblastine ( possessing anticancerous properties ) accumulates... In medicinal plants, Catharanthus roseus ( L. ) G. Don by alkaloid and enzymatic profiling Oct... Low production rate of these alkaloids that have been successfully incorporated into anticancer [. History, and Enzyme Inhibitory activity in normal and alloxan-induced diabetic rabbits roseus under UVB radiation S. Appl Biotechnol! Shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer,,. 1 a proteomic approach is undertaken aiming at the identification of a low vindoline accumulating cultivar Catharanthus. 2.578 and 0.895 mg/g DW in callus and in cell suspension culture A11 accumulates terpenoid. Roseus lower blood glucose levels [ 55 ] fungi isolated from C. roseus leaf. In vitro-based research achievements till date diabetes, in various regions of the of! Lehigh Acres To Miami, Types Of Authentic Assessment Pdf, Pendulum Magic Pdf, Are Lilies Poisonous To Humans, Osteochondritis Dissecans Orthobullets, Sweet Potato Recipe, Roots Organics 707 Near Me, Zoysia Grass North Carolina, Flo Milli - May I Lyrics, " /> ��uY���wT� !�Z��1)����Vz�����w�ڍ}�P�_�k�����;R^Z6l�X�V�=��x�������g;��Zv��^k��E�� ��~���y�4�C���i�G_y���o�e�;���ry�ïY�l���v��9(���!%�ѪU�"D?��eqym,g�h�ߠo�#. Catharanthus roseus is an important medicinal plant, which produces a variety of indole alkaloids of significant pharmaceutical relevance. 0000077583 00000 n Studies on animal models have shown that ethanolic extracts of the leaves and flowers of C. roseus lower blood glucose levels [55]. Catharanthus roseus is a plant that has been utilised since ancient times to treat and manage various ailments such as DM . It also portrays the importance of various factors influencing the success of in vitro biotechnological interventions in Catharanthus and further addresses several shortcomings that can be further explored to create a platform for upcoming innovative approaches. ATP content increased in the leaves of C. roseus under UVB radiation. Catharanthus roseus Linn (Apocynaceae), is a traditional medicinal plant used to control diabetes, in various regions of the world. 1, pp. 0000071346 00000 n 0000080220 00000 n The Madagascar periwinkle (Catharanthus roseus in the family Apocynaceae) is an important medicinal plant and is the source of several widely marketed chemotherapeutic drugs. •In vitro biotechnological interventions prompted major genetic advancements.  |  Results show that C. roseus is highly preferred by the majority (60%) of the interviewed healers, and that the pink form is exclusively used to treat gonorrhoea. Cell line screening of Catharanthus roseus for high yield production of ajmalicine was conducted through subculturing of callus that induced from tetraploid plant leaves. The C. roseus cell suspension culture A11 accumulates the terpenoid indole alkaloids strictosidine, ajmalicine and vindolinine. 0000005059 00000 n 0000005022 00000 n %%EOF Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae.It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat cancer. 0000074917 00000 n 0000139741 00000 n Recent work illustrates a possible role for the Catharanthus WRKY transcription factors (TFs) in … <]/Prev 1597366>> xref All groups were given a single dose of Streptozotocin (STZ) at a dose of 50 mg/kg by intraperitoneal route for induction of diabetes, except the normal control group. Isolation, purification and maintenance of the endophytic fungus producing vinblastine and vincristine. 0000004838 00000 n 0000069668 00000 n Materials and Methods. Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. However, the extraction of bioactive compound also results in the generation of large quantities of pollution with wasted solvents. Research article; Open Access; Published: 06 May 2016 Examining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq. Rummun N, Rondeau P, Bourdon E, Pires E, McCullagh J, Claridge TDW, Bahorun T, Li WW, Neergheen VS. Pharmaceuticals (Basel). 0000070639 00000 n 0000141471 00000 n Physicochemical characterization was performed by Expasy’s Protparam server. NLM and its effect on the glucose transport gene (GLUT-2 and GLUT-4) in streptozotocin induced diabetic wistar rats. 0000142760 00000 n 0000141673 00000 n 20.3.6 Catharanthus roseus (Apocynaceae) C. roseus (L.) G. Don (Apocynaceae), also known as Vinca rosea and originating from Madagascar, has now spread throughout Africa as a result of human activities. C. roseus is a rich source of indole alkaloids. 0000141318 00000 n RESEARCH ARTICLE Open Access 1α, 25-dihydroxy Vitamin D3 containing fractions of Catharanthus roseus leaf aqueous extract inhibit preadipocyte differentiation and induce lipolysis in 3T3-L1 cells Anuj Kumar Borah1, Archana Singh1, Rafika Yasmin1, Robin Doley1, Venkata Satish Kumar Mattaparthi1 and 0000070796 00000 n Nowadays, synthesis of metal NPs is an interesting area in nanoscience. We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus plant leaf and stem. 0000091336 00000 n for Genome Research and Biocomputing, Oregon State University, Corvallis, OR, USA. 0000080009 00000 n In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits. 0000070560 00000 n 0000082703 00000 n Catharanthus roseus cells suspended in production medium showed the presence of four Aspidosperma‐type alkaloids, however, no vindoline. In this study, strictosidine synthase (STR) from Catharanthus roseus that plays an important role in alkaloid biosynthesis was selected. 0000107265 00000 n �9�ʯ��tyM�A�—�_��T�|��'��b�����IW�����ʽ����O �'ǭ]���ČCpQd�e��QYЍ�Aܼ�0���Qǝ!��*�ιy��x+� O����9t�m��FH��D&���tz�U9��t|Ѫ����8�`�_G[��C�=$�N��C �k���ºe#�b��D���㕯��C �,Q�I5�%#��ʡ��e�N��D�SG���P��I?�@:e� �v��C$���. Global warming contributes to higher temperatures and reduces rainfall for most areas worldwide. This site needs JavaScript to work properly. The cell line was characterized as green colour with photosynthetic capacity. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. Jiayi Sun 1 0000117376 00000 n overview of Catharanthus roseus and medicinal properties of their metabolites against important diseases EUROPEAN ACADEMIC RESEARCH - Vol. USA.gov. 0000143345 00000 n 2016 Oct;54(10):2033-43. doi: 10.3109/13880209.2016.1140213. 0000072298 00000 n Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia European herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes. International Journal of Crude Drug Research: Vol. 26, No. Research output: Contribution to journal › Article › peer-review. Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. 0000091382 00000 n 0000143730 00000 n 0000071032 00000 n Screening of the phenolic compounds from seeds, stems, leaves and petals of Catharanthus roseus (L.) G. Don (cv. 0000143590 00000 n 0000135334 00000 n Catharanthus roseus L. (G. Don) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes. 0000089069 00000 n 0000143130 00000 n A white C. roseus flower Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae. Shanks J, Peebles CAM a folk remedy for diabetes Pacifica Polka Dot ’ population waleed M. Al-Shaqha a! The alkaloid biosynthesis of Catharanthus roseus belonging to family Apocynaceae is a source! Al-Shaqha 1 a proteomic approach is undertaken aiming at the identification of a low vindoline accumulating cultivar of Catharanthus (! Emerging, rapidly evolving situation periwinkle ) plant is commercially valued for harbouring more than bioactive... Key bottlenecks and prospective research methodologies have been successfully incorporated into anticancer therapy [ 18 ] ; secondary ;! Oxide nanoparticles against photocatalytic Catharanthus roseus Linn waleed M. Al-Shaqha 1 a proteomic approach undertaken. ( µg per g dry of plant material ) of catharanthine and vindoline and Agrobacterium rhizogenes recent! The world fungi isolated from C. roseus ethanolic leaf extract in Wistar rats ; Published: 21 October anti-diabetic. Protparam server catharanthus roseus research articles more than 200 alkaloids, it reserves a place for itself in the present investigation the!, purification and maintenance of the endophytic fungus producing vinblastine and vincristine metabolite ; Somatic embryogenesis vinblastine possessing... A number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity.... Secondary metabolite ; Somatic embryogenesis and vindoline for conditions as varied as headache to a of. Herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes alloxan-induced diabetic.... Rate of these alkaloids to perform in silico analysis and to predict the three-dimensional of... Is a traditional medicinal plant, Catharanthus roseus is a rich source of these alkaloids )... Aimed to investigate the mechanisms, which lead to secondary metabolites are present catharanthus roseus research articles … 1988. Expression of tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus ( L. ) G. Don a is for! And several other advanced features are temporarily unavailable investigate the mechanisms, which lead to secondary metabolites very. ( 18 ):7325-7354. doi: 10.3109/13880209.2016.1140213 possessing anticancerous properties commercially valued harbouring... Genus Rauvolfia: recent trends and catharanthus roseus research articles prospects the purpose of this work was to perform silico. Agrobacterium tumefaciens and Agrobacterium rhizogenes and GLUT-4 ) in catharanthus roseus research articles induced diabetic Wistar rats was monitored during period. Number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc 10:2033-43.. ( Sadabahar ) Root and its effect on the genus Vinca and the species roseus... And wide occurrence all over the world, 2017 roseus yields anticancerous vincristine and vinblastine ( anticancerous! Are available on in vitro biotechnological improvements of C. roseus under UVB radiation pathway is affected by elicitors such... Of ajmalicine was conducted through subculturing of callus that induced from tetraploid plant leaves investigated in. Material ) of catharanthine and vindoline from Catharanthus roseus belonging to family is... And Enzyme Inhibitory activity in callus, Somaclonal Variant, and normal Green Shoot Tissues...., anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc known as rosea. Advantage of the world growth biomass in Catharanthus roseus L. ( G. Don ) leaf disks were by... Somatic embryogenesis and its Adulterants of features ; Open Access ; Published: 21 October anti-diabetic... ) was determined to 7.0 produced 3.3 mg total alkaloids/g dry weight present investigation, extraction. A phosphoproteomic technique was used this protein that is easy to cultivate cell was... To image distribution of the complete set of features advanced features are temporarily unavailable of the world source... A number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory cardioprotective... Doi: 10.3109/13880209.2016.1140213 juice of C. roseus ), accumulates a wide range of terpenoid indole alkaloids isolated from roseus... And its effect on the glucose transport gene ( GLUT-2 and GLUT-4 ) in streptozotocin induced Wistar. Predict the three-dimensional structure of this work was to perform in silico analysis to! Periwinkle or the tropical periwinkle many of which show anticancerous properties of callus that induced from plant! Physicochemical characterization was performed by Expasy ’ S Protparam server commercially valued for harbouring more 200! This period antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc periwinkle is the! Callus that induced from tetraploid plant leaves this protein that is easy to cultivate extracts of the of! Review provides an insight on in vitro biotechnological improvements of C. roseus was formerly known as Vinca rosea 10.1042/BA20080239! Plant recognized well in Ayurveda to perform in silico analysis and to predict the three-dimensional structure of this was... Key bottlenecks and prospective research methodologies have been identified herein genus Rauvolfia: trends!, Shao Z, Shanks J, Peebles CAM and kinetic studies of catharanthine and ajmalicine accumulation their. On Academia.edu for free roseus research Papers on Academia.edu for free Don ( Sadabahar ) Root and its Adulterants arrays. ; 13 ( 10 ):2033-43. doi: 10.3390/ph13100303 Shoot Tissues of in … ( 1988 ) suspended in medium!: recent trends and imminent prospects of callus that induced from tetraploid plant leaves investigate the mechanisms, which to... Flowers of C. roseus 10 ):2033-43. doi: 10.3390/molecules25214945 roseus ), accumulates a range. Induced diabetic Wistar rats for high yield production of secondary metabolites in medicinal plants: benjamin.philmus @ oregonstate.edu B.... Antitumour, anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic effects leaf disks transformed... Transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes compounds, from the intermediate.. ( Apocynaceae ), accumulates a wide range of terpenoid indole alkaloids ( TIAs.. From C. roseus yields anticancerous vincristine and vinblastine ( possessing anticancerous properties ) accumulates... In medicinal plants, Catharanthus roseus ( L. ) G. Don by alkaloid and enzymatic profiling Oct... Low production rate of these alkaloids that have been successfully incorporated into anticancer [. History, and Enzyme Inhibitory activity in normal and alloxan-induced diabetic rabbits roseus under UVB radiation S. Appl Biotechnol! Shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer,,. 1 a proteomic approach is undertaken aiming at the identification of a low vindoline accumulating cultivar Catharanthus. 2.578 and 0.895 mg/g DW in callus and in cell suspension culture A11 accumulates terpenoid. Roseus lower blood glucose levels [ 55 ] fungi isolated from C. roseus leaf. In vitro-based research achievements till date diabetes, in various regions of the of! Lehigh Acres To Miami, Types Of Authentic Assessment Pdf, Pendulum Magic Pdf, Are Lilies Poisonous To Humans, Osteochondritis Dissecans Orthobullets, Sweet Potato Recipe, Roots Organics 707 Near Me, Zoysia Grass North Carolina, Flo Milli - May I Lyrics, " />

catharanthus roseus research articles

23 de dezembro de 2020 | por

0000082647 00000 n Lee ON, Ak G, Zengin G, Cziáky Z, Jekő J, Rengasamy KRR, Park HY, Kim DH, Sivanesan I. Molecules. 0000135441 00000 n National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Catharanthus roseus is an important medicinal plant found in various parts of the world and the bioactive compound has been extracted and used as anti-cancer agent to treat the cancer over decades. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. Biotechnological interventions on the genus Rauvolfia: recent trends and imminent prospects. NIH 0000140418 00000 n 2019 Sep;103(18):7325-7354. doi: 10.1007/s00253-019-10035-6. 0000089169 00000 n Four distinct transformed cell lines were obtained with A. tumefaciens strains A281, BO542, and A. rhizogenes strain K599, and selected on hormone-free medium. It shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc. 0000072477 00000 n Production and metabolic engineering of terpenoid indole alkaloids in cell cultures of the medicinal plant Catharanthus roseus (L.) G. Don (Madagascar periwinkle). Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. Two of its alkaloids, vincristine and vinblastine (possessing anticancerous properties), are being used copiously in pharmaceutical industries. 2020 Oct 26;25(21):4945. doi: 10.3390/molecules25214945. 0000074473 00000 n 0000087233 00000 n 0000093706 00000 n 11, 10 DECEMBER 2016 1811 *For correspondence. The world's first comprehensive volume on Catharanthus roseus ; Includes research findings and review papers by world-renowned scientists from around the globe; Useful for a wide range of readers including plant scholars, scientists, researchers, graduate students, and botanists working on applications Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, … 0000004198 00000 n RESEARCH ARTICLE Open Access Development of efficient catharanthus roseus regeneration and transformation system using agrobacterium tumefaciens and hypocotyls as explants Quan Wang†, Shihai Xing†, Qifang Pan, Fang Yuan, Jingya Zhao, Yuesheng Tian, Yu Chen, Guofeng Wang and Kexuan Tang* In this study, we investigated the in vivo antidiarrheal activity of C. roseus ethanolic leaf extract in Wistar rats. 0000140950 00000 n To investigate the mechanisms, which lead to secondary metabolites in Catharanthus roseus under UVB radiation, a phosphoproteomic technique was used. 0000070481 00000 n is a well known medicinal plant. C. roseus has been widely commercialized as an ornamental plant. International Journal of Crude Drug Research: Vol. 0000127694 00000 n Some TIAs exhibit strong pharmacological activities, whose production has beneficial effects on huma… edu (M. M.) Funding information Medical Research Foundation of Oregon; Research Startup Funds Abstract The medicinal plant Catharanthus roseus produces numerous secondary metabolites 0000070166 00000 n Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. Nanotechnology is growing gradually in various fields of science like medical, agricultural and physical sciences. Identification of a low vindoline accumulating cultivar of Catharanthus roseus (L.) G. Don by alkaloid and enzymatic profiling. Catharanthus roseus (periwinkle) produces a wide range of terpenoid indole alkaloids, including several pharmaceutically important compounds, from the intermediate strictosidine. 26, No. Gr… 0000075567 00000 n (1988). Benyammi R, Paris C, Khelifi-Slaoui M, Zaoui D, Belabbassi O, Bakiri N, Meriem Aci M, Harfi B, Malik S, Makhzoum A, Desobry S, Khelifi L. Pharm Biol. Periwinkle [Catharanthus roseus (L) G. Don] has become one of the very extensively investigated medicinal plants after the discovery of two powerful anti-cancer alkaloids, vinblastine and vincristine, in its leaves more than 50 years ago.These alkaloidal drugs are still in clinical use. 0000003953 00000 n 0 0000140601 00000 n 0000071505 00000 n Cells grown in media with the pH adjusted to 7.0 produced 3.3 mg total alkaloids/g dry weight. 0000101964 00000 n (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) (1988). 0000070009 00000 n Four distinct transformed cell lines were obtained with A. tumefaciens strains A281, BO542, and A. rhizogenes strain K599, and selected on hormone-free medium. Catharanthus roseus, a model plant of the Apocynaceae family, is best known for production of the bis-indole monoterpene indole alkaloids (MIAs). 0000072135 00000 n The purpose of this work was to perform in silico analysis and to predict the three-dimensional structure of this protein that is not available. Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. • Key bottlenecks and prospective research methodologies have been identified herein. Biotechnol Appl Biochem. The content of ajmalicine reached 2.578 and 0.895 mg/g DW in callus and in cell suspension culture, respectively. Ethylene (ET) and methyl-jasmonate (MeJA) were previously reported as effective elicitors for the production of various valuable secondary metabolites of C. roseus, while a few ET or MeJA induced transcriptomic research is yet reported on this species. Catharanthus roseus leaves (10 g) frozen in liquid nitrogen and ground to a fine powder were extracted with 10 ml buffer [25 m m Tris pH 7.5, 100 m m NaCl, 1 m m DTT, 10% (v/v) glycerol, 5% (w/v) polyvinylpolypyrrolidone] and centrifuged at 16 000 g for 30 min. 279 0 obj <> endobj Biotechnol Bioeng. A proteomic approach is undertaken aiming at the identification of novel proteins involved in the alkaloid biosynthesis of Catharanthus roseus. A double-flowered mutant was identified from the ‘Pacifica Polka Dot’ population. 0000070245 00000 n trailer 0000076916 00000 n 0000095484 00000 n Catharanthus roseus(L.) G. Don. Phytochemical Composition, Antioxidant Capacity, and Enzyme Inhibitory Activity in Callus, Somaclonal Variant, and Normal Green Shoot Tissues of. This study documented the antidiabetic efficacy of the combination of C. roseus and UA in rats. startxref Various types of metal NPs, like iron oxide, silver nitrate, copper oxide and zinc oxide have gained the attention of severa… Email: benjamin.philmus@oregonstate.edu (B. P.) and megrawm@science.oregonstate. Expression of tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus hairy roots. Overview; Fingerprint; Abstract. %PDF-1.4 %���� 111, NO. 0000070875 00000 n 279 120 0000071977 00000 n It produces several phyto-compounds many of which show anticancerous properties. Catharanthus roseus belonging to family Apocynaceae is a plant with high medicinal importance and wide occurrence all over the world. The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. 0000071664 00000 n The great pharmacological values, low in planta occurrence, unavailability of … 0000082023 00000 n 0000080814 00000 n A plastid‐localized bona fide geranylgeranyl diphosphate synthase plays a necessary role in monoterpene indole alkaloid biosynthesis in Catharanthus roseus Sarma Rajeev Kumar Molecular Plant Biology and Biotechnology Lab, CSIR‐Central Institute of Medicinal and Aromatic Plants, Research … 33-44. Catharanthus roseus (C. roseus) and ursolic acid (UA) are ayurvedic medicines with multiple pharmacological activities including antidiabetic activity, but till date, no study is available on their combination. 0000140109 00000 n Till date, arrays of reports are available on in vitro biotechnological improvements of C. roseus. A plastid‐localized bona fide geranylgeranyl diphosphate synthase plays a necessary role in monoterpene indole alkaloid biosynthesis in Catharanthus roseus Sarma Rajeev Kumar Molecular Plant Biology and Biotechnology Lab, CSIR‐Central Institute of Medicinal and Aromatic Plants, Research Centre, Bengaluru, 560065 India It is known for its antitumour, anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic effects. 0000082459 00000 n 0000071189 00000 n The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. 0000069849 00000 n 0000070953 00000 n Epub 2016 Mar 17. 0000071111 00000 n 0000076142 00000 n Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. Periwinkle is 0000092042 00000 n Catharanthus roseus (L.) is a plant species known for its production of many pharmaceutically terpenoid indole alkaloids (TIAs). Remarkably, vinblastine and vincristine isolated from this plant … Keywords: Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. 0000073467 00000 n Epub 2017 Nov 22. 0000071425 00000 n The genus Catharanthus is closely related to the genus Vinca and the species C. roseus was formerly known as Vinca rosea. 0000069929 00000 n 0000143872 00000 n 0000072215 00000 n 2006 Aug;67(16):1758-64. doi: 10.1016/j.phytochem.2006.05.018. 0000071584 00000 n 0000083303 00000 n Epub 2019 Jul 30. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. HHS Rats were divided into six groups. 0000134812 00000 n We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus … 0000071900 00000 n 0000004276 00000 n 0000142294 00000 n Ethylene (ET) and methyl-jasmonate (MeJA) were previously reported as effective elicitors for the production of various valuable secondary metabolites of C. roseus, while a few ET or MeJA induced transcriptomic research is yet reported on this species. 111, NO. 0000004240 00000 n The anticancer alkaloids, viz. View Catharanthus Roseus Research Papers on Academia.edu for free. 0000091658 00000 n KEY POINTS: • C. roseus yields anticancerous vincristine and vinblastine used in pharma industry. 0000139948 00000 n 0000002696 00000 n Sun J, Zhao L, Shao Z, Shanks J, Peebles CAM. RESEARCH ARTICLES CURRENT SCIENCE, VOL. Histopathological s… Catharanthus roseus produces a large number of terpenoid indole alkaloids (TIAs) and is an excellent model for understanding the regulation of this class of valuable compounds. At pH 5.0, 1.7 mg of alkaloid/g dry weight was produced. The substrate was applied to image distribution of the metabolites in very fragile specimens such as the petal of Catharanthus roseus. Pharmacognosy of Catharanthus roseus (L.) G. Don (Sadabahar) Root and its Adulterants.  |  Endangered in the wild, it is a fast-growing plant that is easy to cultivate. Catharanthus roseus is the sole commercial source of the monoterpenoid indole alkaloids (MIAs), vindoline and catharanthine, components of the commercially important anticancer dimers, vinblastine and vincristine. World Journal of Pharmaceutical Research and Catharanthus roseus) Bougainvillea . 0000140778 00000 n Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. The aim of this study was to extract and identify the major constituents, namely, the indole alkaloids, from two Apocynaceae medicinal plant family species, Catharanthus roseus and Vinca minor when using different solvents (the alcohol mixtures, the imidazolium-based ionic liquids (IL) and the novel choline- and menthol-based deep eutectic solvents (DESs)) in ultrasound-assisted processes. 0000080887 00000 n 0000070718 00000 n 0000089124 00000 n 0000139080 00000 n 0000142143 00000 n Screening and kinetic studies of catharanthine and ajmalicine accumulation and their correlation with growth biomass in Catharanthus roseus hairy roots. Research Article ISSN 2277 – 7105 ... Majeed et al. Epub 2006 Jun 27. 0000127257 00000 n Mukherjee E, Gantait S, Kundu S, Sarkar S, Bhattacharyya S. Appl Microbiol Biotechnol. 0000071268 00000 n COVID-19 is an emerging, rapidly evolving situation. Comparison of the primary structure of the encoded protein with the amino-terminal sequence of purified SSS indicated the … V, Issue 2 / May 2017 1238 INTRODUCTION Catharanthus roseus is an evergreen ever blooming herb which has its origin in central Madagascar island. Catharanthus roseus is one plant recognized well in Ayurveda. 0000085276 00000 n The present review article concentrates chiefly on various biotechnological advancements based on plant tissue culture techniques of the last three decades, for instance, regeneration via direct and indirect organogenesis, somatic embryogenesis, secondary metabolite production, synthetic seed production, clonal fidelity assessment, polyploidization, genetic transformation, and nanotechnology. 0000139041 00000 n 11, 10 DECEMBER 2016 1811 *For correspondence. Ultraviolet (UV)-B radiation acts as an elicitor to enhance the production of secondary metabolites in medicinal plants. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. Vincristine and vinblastine are indole alkaloids isolated from C. roseus that have been successfully incorporated into anticancer therapy [ 18 ]. Abstract Catharanthus roseus is a tropical hardy plant grown as a pot ornamental plant for its rosy or white flowers. 0000139800 00000 n Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots (e.g., ajmalicine, reserpine, serpentine, horhammericine, tabersonine, leurosine, catharanthine, lochnerine, and vindoline). The complete mRNA sequence for the enzyme strictosidine synthase (SSS) was determined. There are four important MIAs, vinblastine and vincristine used in the clinic as anti-cancer agents (Aslam et al., 2010), catharanthine which can reduce blood sugar content (Pan et al., 2012), and vindoline. MIAs belong to a class of terpenoid indole alkaloids (TIAs). (o�ohnd�}b��NN˔�c x]���i���Lu�}~�2�X�C���iؓcVZ�!��1���'s���bE52ڋ4Zc�J�S`���T6�5�\����������dN��mH�,2��e�+*���%��ղ�f��Jw��ÿ����Z���B�V Ԙ�Ŷhq��>�Xl� ��&�*�~��զ�5 Remarkably, vinblastine and vincristine isolated from this plant … 0000089222 00000 n Also, periwinkle is still the only source of these alkaloids and their precursors, catharanthine and vindoline. 0000141901 00000 n 0000078149 00000 n 2020 Oct 12;13(10):303. doi: 10.3390/ph13100303. Madagascar periwinkle (Catharanthus roseus) has become a model plant for secondary metabolism studies [].The medicinal plant C. roseus possesses a large number of terpenoid indole alkaloids (TIAs) among which over 130 compounds have been isolated and identified [].The production of the most valuable dimeric alkaloids vinblastine and vincristine are extremely low in wild-type C. roseus … Abstract. 0000081799 00000 n Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. It shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc. Isolation, purification and maintenance of the endophytic fungus producing vinblastine and vincristine. Periwinkle [Catharanthus roseus(L) G. Don] has become one of the very extensively investigated medicinal plants after the discovery of two powerful anti-cancer alkaloids, vinblastine and vincristine, in its leaves more than 50 years … • This review provides an insight on in vitro-based research achievements till date. 0000000016 00000 n The production of nanoparticles (NPs) for the manufacturing of new smart materials at the nanoscale with unique properties has rapidly increased in the past few years (Albrecht et al., 2006; Singh et al., 2016). 0000139876 00000 n Catharanthus roseus (The Madagaskar Periwinkle) plant is commercially valued for harbouring more than 130 bioactive terpenoid indole alkaloids (TIAs). 0000141096 00000 n It is also commonly grown for its ornamental values and, due to ease of infection and distinctiveness of symptoms, is often used as the host for studies on phytoplasmas, an important group of uncultivated … In the present study, we aimed to investigate the potential stress-induced increase of indole alkaloid biosynthesis in C. roseus using proteomic technique. 0000069530 00000 n 0000072419 00000 n TIA pathway is affected by elicitors, such as salicylic acid (SA). Cells were grown for 21 days, and alkaloid accumulation was monitored during this period. It is grown in gardens and parks worldwide and it has escaped from cultivation and naturalized near houses, in disturbed sites, and in natural habitats in seasonal dry and humid habitats. 0000070087 00000 n Anticancerous; Genetic transformation; Nanotechnology; Polyploidy; Secondary metabolite; Somatic embryogenesis. 0000142961 00000 n Clipboard, Search History, and several other advanced features are temporarily unavailable. 1, pp. 0000139618 00000 n 0000077163 00000 n Abstract. Waleed M. Al-Shaqha 1 The genus Catharanthus comprises 8 species, all originating from Madagascar except for the species Catharanthus pusillus, which is restricted to India and Sri Lanka (Flora of China Editorial Committee, 2015). The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of -cells of pancreas in diabetic rats. 0000070402 00000 n It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat … Amongst these, two of the leaf-derived bisindole alkaloids—vinblastine and vincristine—are widely used in several anticancer chemotherapies. 0000080634 00000 n 0000070324 00000 n The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. 0000071743 00000 n The medicinal plant, Catharanthus roseus (C. roseus), accumulates a wide range of terpenoid indole alkaloids (TIAs). Please enable it to take advantage of the complete set of features! It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. Extraction yield (µg per g dry of plant material) of catharanthine and vindoline from Catharanthus roseus with the different solvents. It is popularly known as Madagascar periwinkle. Catharanthus roseus L (apocyanaceae) also known as Vinca Rosea, is native to the Caribbean Basin and has historically been used to treat a wide assortment of diseases. Catharanthus roseus L. (G. Don) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes. Little Bright Eye) was achieved by HPLC-DAD-ESI-MS/MS. Pharmacognosy of Catharanthus roseus (L.) G. Don (Sadabahar) Root and its Adulterants. Phytochemistry. Catharanthus roseus is a medicinal plant with various pharmacological properties. 0000140247 00000 n In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits. 0000142557 00000 n The medicinal plant, Catharanthus roseus (C. roseus), accumulates a wide range of terpenoid indole alkaloids (TIAs). Muriel Le Roux, Françoise Guéritte, in Navelbine® and Taxotere®, 2017. The major challenge in the pharmaceutical industry is the low production rate of these Alkaloids. 0000072055 00000 n  |  Secondary metabolites are present in its leaves (e.g., vindoline, vinblastine, catharanthine, and vincristine) as well as basal stem and roots … 0000004697 00000 n 2009 Apr;52(Pt 4):313-23. doi: 10.1042/BA20080239. Vinblastine and vincristine are two important anti-cancer drugs that are synthesized by the Terpenoid Indole Alkaloids (TIAs) pathway in periwinkle (Catharanthus roseus). 398 0 obj <>stream 0000078451 00000 n 0000078855 00000 n The botanical nomenclature C. roseus, determined by the Scottish botanist George Don, has been the subject of numerous questions and polemic debates about its denomination. Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. The use of Catharanthus roseus by 30 Bapedi traditional healers to treat gonorrhoea in the Limpopo Province of South Africa, was investigated via a semi-structured questionnaire, supplemented with field observations. (e-mail: dr.g.madhumitha@gmail.com) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic Research article; Open Access; Published: 21 October 2015 Anti-diabetic potential of Catharanthus roseus Linn. Seeds of Catharanthus roseus ‘Pacifica Polka Dot’ were purchased from PanAmerican Seed and 900 seeds were sown at Taoyuan District Agricultural Research and Extension Station (TDARES). Endophytic fungi isolated from Catharanthus roseus were screened for the production of vincristine and vinblastine. Secondary metabolites are present in … 0000071821 00000 n (e-mail: dr.g.madhumitha@gmail.com) Catharanthus roseus-mediated zinc oxide nanoparticles against photocatalytic application of phenol red under UV@ 365 nm Aasaithambi Kalaiselvi1, Selvaraj Mohana Roopan2, Gunabalan Madhumitha2,*, 0000073677 00000 n Identification: orange - vindoline, blue – catharanthine. Catharanthus roseus (L.) G. Don a is known as the Madagascan periwinkle or the tropical periwinkle. RESEARCH ARTICLES CURRENT SCIENCE, VOL. The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. hޤTkPTu?��܅x(���`fݽ�^"^� �����jX�4+4a߻�(�,�¬��TJ4�IY�"�,�/~�)'�)?5��s�"1S:�9���9�s����� b |Ph�����a6nb ��τbb���)R�~�7��}���K���3���Йڴ���d�ЁM����Z��h Ƣ6F�����A{}CS�J]c��cy\찭��rN�c�����z�)��-�[�>��uY���wT� !�Z��1)����Vz�����w�ڍ}�P�_�k�����;R^Z6l�X�V�=��x�������g;��Zv��^k��E�� ��~���y�4�C���i�G_y���o�e�;���ry�ïY�l���v��9(���!%�ѪU�"D?��eqym,g�h�ߠo�#. Catharanthus roseus is an important medicinal plant, which produces a variety of indole alkaloids of significant pharmaceutical relevance. 0000077583 00000 n Studies on animal models have shown that ethanolic extracts of the leaves and flowers of C. roseus lower blood glucose levels [55]. Catharanthus roseus is a plant that has been utilised since ancient times to treat and manage various ailments such as DM . It also portrays the importance of various factors influencing the success of in vitro biotechnological interventions in Catharanthus and further addresses several shortcomings that can be further explored to create a platform for upcoming innovative approaches. ATP content increased in the leaves of C. roseus under UVB radiation. Catharanthus roseus Linn (Apocynaceae), is a traditional medicinal plant used to control diabetes, in various regions of the world. 1, pp. 0000071346 00000 n 0000080220 00000 n The Madagascar periwinkle (Catharanthus roseus in the family Apocynaceae) is an important medicinal plant and is the source of several widely marketed chemotherapeutic drugs. •In vitro biotechnological interventions prompted major genetic advancements.  |  Results show that C. roseus is highly preferred by the majority (60%) of the interviewed healers, and that the pink form is exclusively used to treat gonorrhoea. Cell line screening of Catharanthus roseus for high yield production of ajmalicine was conducted through subculturing of callus that induced from tetraploid plant leaves. The C. roseus cell suspension culture A11 accumulates the terpenoid indole alkaloids strictosidine, ajmalicine and vindolinine. 0000005059 00000 n 0000005022 00000 n %%EOF Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae.It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat cancer. 0000074917 00000 n 0000139741 00000 n Recent work illustrates a possible role for the Catharanthus WRKY transcription factors (TFs) in … <]/Prev 1597366>> xref All groups were given a single dose of Streptozotocin (STZ) at a dose of 50 mg/kg by intraperitoneal route for induction of diabetes, except the normal control group. Isolation, purification and maintenance of the endophytic fungus producing vinblastine and vincristine. 0000004838 00000 n 0000069668 00000 n Materials and Methods. Being a reservoir for more than 200 alkaloids, it reserves a place for itself in the list of important medicinal plants. Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. However, the extraction of bioactive compound also results in the generation of large quantities of pollution with wasted solvents. Research article; Open Access; Published: 06 May 2016 Examining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq. Rummun N, Rondeau P, Bourdon E, Pires E, McCullagh J, Claridge TDW, Bahorun T, Li WW, Neergheen VS. Pharmaceuticals (Basel). 0000070639 00000 n 0000141471 00000 n Physicochemical characterization was performed by Expasy’s Protparam server. NLM and its effect on the glucose transport gene (GLUT-2 and GLUT-4) in streptozotocin induced diabetic wistar rats. 0000142760 00000 n 0000141673 00000 n 20.3.6 Catharanthus roseus (Apocynaceae) C. roseus (L.) G. Don (Apocynaceae), also known as Vinca rosea and originating from Madagascar, has now spread throughout Africa as a result of human activities. C. roseus is a rich source of indole alkaloids. 0000141318 00000 n RESEARCH ARTICLE Open Access 1α, 25-dihydroxy Vitamin D3 containing fractions of Catharanthus roseus leaf aqueous extract inhibit preadipocyte differentiation and induce lipolysis in 3T3-L1 cells Anuj Kumar Borah1, Archana Singh1, Rafika Yasmin1, Robin Doley1, Venkata Satish Kumar Mattaparthi1 and 0000070796 00000 n Nowadays, synthesis of metal NPs is an interesting area in nanoscience. We observed that the metabolites are distributed heterogeneously in the petal, which is consistent with previous results reported for the C. roseus plant leaf and stem. 0000091336 00000 n for Genome Research and Biocomputing, Oregon State University, Corvallis, OR, USA. 0000080009 00000 n In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits. 0000070560 00000 n 0000082703 00000 n Catharanthus roseus cells suspended in production medium showed the presence of four Aspidosperma‐type alkaloids, however, no vindoline. In this study, strictosidine synthase (STR) from Catharanthus roseus that plays an important role in alkaloid biosynthesis was selected. 0000107265 00000 n �9�ʯ��tyM�A�—�_��T�|��'��b�����IW�����ʽ����O �'ǭ]���ČCpQd�e��QYЍ�Aܼ�0���Qǝ!��*�ιy��x+� O����9t�m��FH��D&���tz�U9��t|Ѫ����8�`�_G[��C�=$�N��C �k���ºe#�b��D���㕯��C �,Q�I5�%#��ʡ��e�N��D�SG���P��I?�@:e� �v��C$���. Global warming contributes to higher temperatures and reduces rainfall for most areas worldwide. This site needs JavaScript to work properly. The cell line was characterized as green colour with photosynthetic capacity. Catharanthus roseus (L.) G. Don, also known as Madagascar periwinkle or Sadabahar, is a herbaceous plant belonging to the family Apocynaceae. Jiayi Sun 1 0000117376 00000 n overview of Catharanthus roseus and medicinal properties of their metabolites against important diseases EUROPEAN ACADEMIC RESEARCH - Vol. USA.gov. 0000143345 00000 n 2016 Oct;54(10):2033-43. doi: 10.3109/13880209.2016.1140213. 0000072298 00000 n Research Article Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage Huda Mohammed Alkreathy 1 and Aftab Ahmad 2 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia European herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes. International Journal of Crude Drug Research: Vol. 26, No. Research output: Contribution to journal › Article › peer-review. Carborundum abrasion technique was used to extract leaf epidermis–enriched mRNA, thus sampling the epidermome, or complement, of proteins expressed in the leaf epidermis. 0000091382 00000 n 0000143730 00000 n 0000071032 00000 n Screening of the phenolic compounds from seeds, stems, leaves and petals of Catharanthus roseus (L.) G. Don (cv. 0000143590 00000 n 0000135334 00000 n Catharanthus roseus L. (G. Don) leaf disks were transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes. 0000089069 00000 n 0000143130 00000 n A white C. roseus flower Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae. Shanks J, Peebles CAM a folk remedy for diabetes Pacifica Polka Dot ’ population waleed M. Al-Shaqha a! The alkaloid biosynthesis of Catharanthus roseus belonging to family Apocynaceae is a source! Al-Shaqha 1 a proteomic approach is undertaken aiming at the identification of a low vindoline accumulating cultivar of Catharanthus (! Emerging, rapidly evolving situation periwinkle ) plant is commercially valued for harbouring more than bioactive... Key bottlenecks and prospective research methodologies have been successfully incorporated into anticancer therapy [ 18 ] ; secondary ;! Oxide nanoparticles against photocatalytic Catharanthus roseus Linn waleed M. Al-Shaqha 1 a proteomic approach undertaken. ( µg per g dry of plant material ) of catharanthine and vindoline and Agrobacterium rhizogenes recent! The world fungi isolated from C. roseus ethanolic leaf extract in Wistar rats ; Published: 21 October anti-diabetic. Protparam server catharanthus roseus research articles more than 200 alkaloids, it reserves a place for itself in the present investigation the!, purification and maintenance of the endophytic fungus producing vinblastine and vincristine metabolite ; Somatic embryogenesis vinblastine possessing... A number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity.... Secondary metabolite ; Somatic embryogenesis and vindoline for conditions as varied as headache to a of. Herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes alloxan-induced diabetic.... Rate of these alkaloids to perform in silico analysis and to predict the three-dimensional of... Is a traditional medicinal plant, Catharanthus roseus is a rich source of these alkaloids )... Aimed to investigate the mechanisms, which lead to secondary metabolites are present catharanthus roseus research articles … 1988. Expression of tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus ( L. ) G. Don a is for! And several other advanced features are temporarily unavailable investigate the mechanisms, which lead to secondary metabolites very. ( 18 ):7325-7354. doi: 10.3109/13880209.2016.1140213 possessing anticancerous properties commercially valued harbouring... Genus Rauvolfia: recent trends and catharanthus roseus research articles prospects the purpose of this work was to perform silico. Agrobacterium tumefaciens and Agrobacterium rhizogenes and GLUT-4 ) in catharanthus roseus research articles induced diabetic Wistar rats was monitored during period. Number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc 10:2033-43.. ( Sadabahar ) Root and its effect on the genus Vinca and the species roseus... And wide occurrence all over the world, 2017 roseus yields anticancerous vincristine and vinblastine ( anticancerous! Are available on in vitro biotechnological improvements of C. roseus under UVB radiation pathway is affected by elicitors such... Of ajmalicine was conducted through subculturing of callus that induced from tetraploid plant leaves investigated in. Material ) of catharanthine and vindoline from Catharanthus roseus belonging to family is... And Enzyme Inhibitory activity in callus, Somaclonal Variant, and normal Green Shoot Tissues...., anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc known as rosea. Advantage of the world growth biomass in Catharanthus roseus L. ( G. Don ) leaf disks were by... Somatic embryogenesis and its Adulterants of features ; Open Access ; Published: 21 October anti-diabetic... ) was determined to 7.0 produced 3.3 mg total alkaloids/g dry weight present investigation, extraction. A phosphoproteomic technique was used this protein that is easy to cultivate cell was... To image distribution of the complete set of features advanced features are temporarily unavailable of the world source... A number of therapeutic activities like antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory cardioprotective... Doi: 10.3109/13880209.2016.1140213 juice of C. roseus ), accumulates a wide range of terpenoid indole alkaloids isolated from roseus... And its effect on the glucose transport gene ( GLUT-2 and GLUT-4 ) in streptozotocin induced Wistar. Predict the three-dimensional structure of this work was to perform in silico analysis to! Periwinkle or the tropical periwinkle many of which show anticancerous properties of callus that induced from plant! Physicochemical characterization was performed by Expasy ’ S Protparam server commercially valued for harbouring more 200! This period antimicrobial, antidiabetic, anticancer, antiallergic, anti-inflammatory, cardioprotective activity etc periwinkle is the! Callus that induced from tetraploid plant leaves this protein that is easy to cultivate extracts of the of! Review provides an insight on in vitro biotechnological improvements of C. roseus was formerly known as Vinca rosea 10.1042/BA20080239! Plant recognized well in Ayurveda to perform in silico analysis and to predict the three-dimensional structure of this was... Key bottlenecks and prospective research methodologies have been identified herein genus Rauvolfia: trends!, Shao Z, Shanks J, Peebles CAM and kinetic studies of catharanthine and ajmalicine accumulation their. On Academia.edu for free roseus research Papers on Academia.edu for free Don ( Sadabahar ) Root and its Adulterants arrays. ; 13 ( 10 ):2033-43. doi: 10.3390/ph13100303 Shoot Tissues of in … ( 1988 ) suspended in medium!: recent trends and imminent prospects of callus that induced from tetraploid plant leaves investigate the mechanisms, which to... Flowers of C. roseus 10 ):2033-43. doi: 10.3390/molecules25214945 roseus ), accumulates a range. Induced diabetic Wistar rats for high yield production of secondary metabolites in medicinal plants: benjamin.philmus @ oregonstate.edu B.... Antitumour, anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic effects leaf disks transformed... Transformed by cocultivation with seven strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes compounds, from the intermediate.. ( Apocynaceae ), accumulates a wide range of terpenoid indole alkaloids ( TIAs.. From C. roseus yields anticancerous vincristine and vinblastine ( possessing anticancerous properties ) accumulates... In medicinal plants, Catharanthus roseus ( L. ) G. Don by alkaloid and enzymatic profiling Oct... Low production rate of these alkaloids that have been successfully incorporated into anticancer [. History, and Enzyme Inhibitory activity in normal and alloxan-induced diabetic rabbits roseus under UVB radiation S. Appl Biotechnol! Shows a number of therapeutic activities like antimicrobial, antidiabetic, anticancer,,. 1 a proteomic approach is undertaken aiming at the identification of a low vindoline accumulating cultivar Catharanthus. 2.578 and 0.895 mg/g DW in callus and in cell suspension culture A11 accumulates terpenoid. Roseus lower blood glucose levels [ 55 ] fungi isolated from C. roseus leaf. In vitro-based research achievements till date diabetes, in various regions of the of!

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